Rotenone-induced nigrostriatal toxicity is reduced by methylene blue
نویسندگان
چکیده
منابع مشابه
Methylene blue counteracts H2S toxicity-induced cardiac depression by restoring L-type Ca channel activity.
We have previously reported that methylene blue (MB) can counteract hydrogen sulfide (H2S) intoxication-induced circulatory failure. Because of the multifarious effects of high concentrations of H2S on cardiac function, as well as the numerous properties of MB, the nature of this interaction, if any, remains uncertain. The aim of this study was to clarify 1) the effects of MB on H2S-induced car...
متن کاملMethylene blue-induced phototoxicity: an unrecognized complication.
OBJECTIVE To describe photosensitization after prenatal exposure to a toxic amount of methylene blue and to alert pediatricians that, in a review of the literature, photosensitization (which this dye is capable of) has not been reported as a complication of prenatal exposure. DESIGN AND PATIENTS A descriptive report of physical findings and significant laboratory tests in a very low birth wei...
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Hypotension in septic shock is a reflection of unregulated nitric oxide (NO) production and vascular smooth muscle guanylyl cyclase activation. We examined the effect of methylene blue on lipopolysaccharide (LPS)-induced shock in anesthetized rabbits. Shock was induced with 150 micrograms/kg LPS after measurement of mean arterial pressure, platelet cGMP, and total plasma NO (nitrogen monoxide+S...
متن کاملRotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons.
In this study, we have examined the effects of rotenone in primary cultures of hippocampal and dopaminergic neurons in order to obtain insights into the possible mechanisms underlying the neurotoxic effects of this pesticide. The results obtained indicate that a 48-h exposure to rotenone (0.1 microM) produces a complete and selective suppression of axon formation. This effect was dose dependent...
متن کاملValeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.
In this study, we investigated the potential protective effects of Valeriana officinalis (V. officinalis) against the toxicity induced by rotenone in Drosophila melanogaster (D. melanogaster). Adult wild-type flies were concomitantly exposed to rotenone (500 μM) and V. officinalis aqueous extract (10mg/mL) in the food during 7 days. Rotenone-fed flies had a worse performance in the negative geo...
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ژورنال
عنوان ژورنال: Journal of Neurorestoratology
سال: 2014
ISSN: 2324-2426
DOI: 10.2147/jn.s49207